Deletions on mouse Yq lead to upregulation of multiple X- and Y-linked transcripts in spermatids.

Ellis, Peter J.I. and Clemente, Emily J. and Ball, Penny and Touré, Aminata and Ferguson, Lydia and Turner, James M.A. and Loveland, Kate L. and Affara, Nabeel A. and Burgoyne, Paul S. (2005) Deletions on mouse Yq lead to upregulation of multiple X- and Y-linked transcripts in spermatids. Human molecular genetics, 14 (18). pp. 2705-15. ISSN 0964-6906. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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Abstract

Deletions on the mouse Y-chromosome long arm (MSYq) lead to teratozoospermia and in severe cases to infertility. We find that the downstream transcriptional changes in the testis resulting from the loss of MSYq-encoded transcripts involve upregulation of multiple X- and Y-linked spermatid-expressed genes, but not related autosomal genes. Therefore, this indicates that in normal males, there is a specific repression of X and Y (gonosomal) transcription in post-meiotic cells, which depends on MSYq-encoded transcripts. Together with the known sex ratio skew in favour of females in the offspring of fertile MSYqdel males, this strongly suggests the existence of an intragenomic conflict between X- and Y-linked genes. Two potential antagonists in this conflict are the X-linked multicopy gene Xmr and its multicopy MSYq-linked relative Sly, which are upregulated and downregulated, respectively, in the testes of MSYqdel males. Xmr is also expressed during meiotic sex chromosome inactivation (MSCI), indicating a link between the MSCI and the MSYq-dependent gonosomal repression in spermatids. We therefore propose that this repression and MSCI itself are evolutionary adaptations to maintain a normal sex ratio in the face of X/Y antagonism.

Item Type: Article
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QH Natural history > QH426 Genetics
Q Science > QP Physiology (Living systems) > QP506 Molecular biology
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Peter Ellis
Date Deposited: 19 Jan 2015 16:03 UTC
Last Modified: 21 Jan 2015 13:59 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/46564 (The current URI for this page, for reference purposes)
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