Spermatogenesis and sex chromosome gene content: an evolutionary perspective.

Ellis, Peter J.I. and Affara, Nabeel A. (2006) Spermatogenesis and sex chromosome gene content: an evolutionary perspective. Human fertility (Cambridge, England), 9 (1). pp. 1-7. ISSN 1464-7273. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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Official URL
http://informahealthcare.com/doi/abs/10.1080/14647...

Abstract

Mammalian sex chromosomes are highly diverged and heteromorphic: a comparatively large and gene-rich X chromosome contrasting with a small, largely heterochromatic and degenerate Y chromosome. Both gonosomes are however uniquely important in male-specific functions such as spermatogenesis. In this review, we examine the evolutionary pressures that have driven the divergence of the sex chromosomes from their ancestral state, and show how these have shaped the gene content of both chromosomes. Their shared history of gene acquisition and loss, differentiation, degeneration and intragenomic warfare has far-reaching consequences for their functionality in spermatogenesis, and may also have potential clinical implications.

Item Type: Article
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QH Natural history > QH426 Genetics
Q Science > QP Physiology (Living systems) > QP506 Molecular biology
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Peter Ellis
Date Deposited: 19 Jan 2015 16:15 UTC
Last Modified: 21 Jan 2015 13:58 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/46561 (The current URI for this page, for reference purposes)
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