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Comparative genomics reveals insights into avian genome evolution and adaptation

Zhang, Guojie, Li, Cai, Li, Qiye, Li, Bo, Larkin, Denis M., Lee, Chul, Storz, Jay F, Antunes, Agostinho, Greenwold, Matthew J, Meredith, Robert W, and others. (2014) Comparative genomics reveals insights into avian genome evolution and adaptation. Science, 346 (6215). pp. 1311-1320. ISSN 0036-8075. (doi:10.1126/science.1251385) (KAR id:46268)

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Birds are the most species-rich class of tetrapod vertebrates and have wide relevance across many research fields. We explored bird macroevolution using full genomes from 48 avian species representing all major extant clades. The avian genome is principally characterized by its constrained size, which predominantly arose because of lineage-specific erosion of repetitive elements, large segmental deletions, and gene loss. Avian genomes furthermore show a remarkably high degree of evolutionary stasis at the levels of nucleotide sequence, gene synteny, and chromosomal structure. Despite this pattern of conservation, we detected many non-neutral evolutionary changes in protein-coding genes and noncoding regions. These analyses reveal that pan-avian genomic diversity covaries with adaptations to different lifestyles and convergent evolution of traits.

Item Type: Article
DOI/Identification number: 10.1126/science.1251385
Subjects: Q Science > QH Natural history
Q Science > QH Natural history > QH426 Genetics
Q Science > QL Zoology
Divisions: Divisions > Division of Natural Sciences > Biosciences
Signature Themes: Food Systems, Natural Resources and Environment
Funders: [UNSPECIFIED] Marie Curie International Incoming Fellowship (MCIIF)
[UNSPECIFIED] Danish National Research Foundation (DNRF)
[UNSPECIFIED] Lundbeck Foundation (LB)
[UNSPECIFIED] Danish Council for Independent Research (DCIR)
[UNSPECIFIED] Howard Hughes Medical Institute and NIH Directors Pioneer Award (HHMI & NIHDPA)
Depositing User: Mike Romanov
Date Deposited: 20 Dec 2014 11:39 UTC
Last Modified: 20 Jul 2021 12:28 UTC
Resource URI: (The current URI for this page, for reference purposes)
Larkin, Denis M.:
Farré, Marta:
Romanov, Michael N:
Griffin, Darren K.:
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