Expanding the hoogsteen edge of 2'-deoxyguanosine: Consequences for G-quadruplex formation

Gubala, V., Betancourt, J.E., Rivera, J.M. (2004) Expanding the hoogsteen edge of 2'-deoxyguanosine: Consequences for G-quadruplex formation. Organic Letters, 6 (25). pp. 4735-4738. ISSN 1523-7060. (doi:10.1021/ol048013v) (KAR id:45250)

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Official URL: http://dx.doi.org/10.1021/ol048013v

Abstract

(Chemical Equation Presented) The synthesis and self-assembling properties of 8-aryl-2'-deoxyguanosine derivatives are described. Our studies suggest that a properly placed acetyl group can increase the stability and specificity of the resulting G-quadruplex supramolecules by enhancing noncovalent interactions such as hydrogen bonds and Ï?-stacking.

Item Type:	Article
DOI/Identification number:	10.1021/ol048013v
Additional information:	Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Org. Lett. [Field not mapped to EPrints] C2 - 15575673 [Field not mapped to EPrints] AD - Department of Chemistry, University of Puerto Rico, RÃo Piedras Campus, RÃo Piedras, 00931, Puerto Rico [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled keywords:	acetic acid derivative, deoxyguanosine, article, chemical interaction, chemical structure, hydrogen bond, synthesis, Deoxyguanosine, Hydrogen Bonding, Nucleic Acid Conformation, Solutions, Temperature
Institutional Unit:	Schools > Medway School of Pharmacy
Former Institutional Unit:	Divisions > Division of Natural Sciences > Medway School of Pharmacy
Depositing User:	Vladimir Gubala
Date Deposited:	14 Dec 2017 21:45 UTC
Last Modified:	20 May 2025 09:54 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/45250 (The current URI for this page, for reference purposes)

University of Kent Author Information

Gubala, V..

Creator's ORCID:	https://orcid.org/0000-0001-6301-3632
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