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Synthesis of 8-heteroaryl-2'-deoxyguanosine derivatives

Hobley, G., Gubala, V., Rivera-Sánchez, M.D.C., Rivera, J.M. (2008) Synthesis of 8-heteroaryl-2'-deoxyguanosine derivatives. Synlett, (10). pp. 1510-1514. ISSN 0936-5214. (doi:10.1055/s-2007-1077795) (KAR id:45246)

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We describe the synthesis of 8-heteroaromatic-2'-deoxyguanosine analogues using Suzuki-Miyaura or Stille conditions. Unprotected and protected 8-bromo-2â?²-deoxyguanosine was coupled with commercially available heteroarylboronic acids or the trialkyltin derivatives of 2-pyridylbromides either with or without microwave irradiation in good yields.

Item Type: Article
DOI/Identification number: 10.1055/s-2007-1077795
Additional information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Synlett [Field not mapped to EPrints] AD - Department of Chemistry, College of Natural Sciences, University of Puerto Rico, Rio Piedras Campus, San Juan 00931, Puerto Rico [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled keywords: Coupling, Nucleobases, Nucleosides, Palladium, Stille reaction, 8 bromo 2' deoxyguanosine, alkyl group, boronic acid derivative, deoxyguanosine derivative, polycyclic aromatic hydrocarbon derivative, pyridine derivative, tin derivative, article, chemical reaction, microwave irradiation, quantum yield, reaction analysis, Stille reaction, suzuki miyaura reaction, synthesis
Divisions: Divisions > Division of Natural Sciences > Medway School of Pharmacy
Depositing User: Vladimir Gubala
Date Deposited: 14 Dec 2017 21:27 UTC
Last Modified: 16 Nov 2021 10:18 UTC
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