The South Asian Genome

Zhi, Degui, Chambers, John C., Abbott, James, Zhang, Weihua, Turro, Ernest, Scott, William R., Tan, Sian-Tsung, Afzal, Uzma, Afaq, Saima, Loh, Marie, and others. (2014) The South Asian Genome. PLoS ONE, 9 (8). Article Number 102645. ISSN 1932-6203. (doi:10.1371/journal.pone.0102645) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:44918)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL: http://dx.doi.org/10.1371/journal.pone.0102645

Abstract

The genetic sequence variation of people from the Indian subcontinent who comprise one-quarter of the world's population, is not well described. We carried out whole genome sequencing of 168 South Asians, along with whole-exome sequencing of 147 South Asians to provide deeper characterisation of coding regions. We identify 12,962,155 autosomal sequence variants, including 2,946,861 new SNPs and 312,738 novel indels. This catalogue of SNPs and indels amongst South Asians provides the first comprehensive map of genetic variation in this major human population, and reveals evidence for selective pressures on genes involved in skin biology, metabolism, infection and immunity. Our results will accelerate the search for the genetic variants underlying susceptibility to disorders such as type-2 diabetes and cardiovascular disease which are highly prevalent amongst South Asians.

Item Type:	Article
DOI/Identification number:	10.1371/journal.pone.0102645
Subjects:	Q Science
Divisions:	Divisions > Division of Natural Sciences > Biosciences
Depositing User:	Mark Wass
Date Deposited:	19 Nov 2014 19:29 UTC
Last Modified:	17 Aug 2022 10:57 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/44918 (The current URI for this page, for reference purposes)

University of Kent Author Information

Wass, Mark N..

Creator's ORCID:	https://orcid.org/0000-0001-5428-6479
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