Analyses of pig genomes provide insight into porcine demography and evolution

Groenen, Martien A. M. and Archibald, Alan L. and Uenishi, Hirohide and Tuggle, Christopher K. and Takeuchi, Yasuhiro and Rothschild, Max F. and Rogel-Gaillard, Claire and Park, Chankyu and Milan, Denis and Megens, Hendrik-Jan and Li, Shengting and Larkin, Denis M. and Kim, Heebal and Frantz, Laurent A. F. and Caccamo, Mario and Ahn, Hyeonju and Aken, Bronwen L. and Anselmo, Anna and Anthon, Christian and Auvil, Loretta and Badaoui, Bouabid and Beattie, Craig W. and Bendixen, Christian and Berman, Daniel and Blecha, Frank and Blomberg, Jonas and Bolund, Lars and Bosse, Mirte and Botti, Sara and Bujie, Zhan and Bystrom, Megan and Capitanu, Boris and Carvalho-Silva, Denise and Chardon, Patrick and Chen, Celine and Cheng, Ryan and Choi, Sang-Haeng and Chow, William and Clark, Richard C. and Clee, Christopher and Crooijmans, Richard P.M.A. and Dawson, Harry D. and Dehais, Patrice and De Sapio, Fioravante and Dibbits, Bert and Drou, Nizar and Du, Zhi-Qiang and Eversole, Kellye and Fadista, João and Fairley, Susan and Faraut, Thomas and Faulkner, Geoffrey J. and Fowler, Katie E. and Fredholm, Merete and Fritz, Eric and Gilbert, James G. R. and Giuffra, Elisabetta and Gorodkin, Jan and Griffin, Darren K. and Harrow, Jennifer L. and Hayward, Alexander and Howe, Kerstin and Hu, Zhi-Liang and Humphray, Sean J. and Hunt, Toby and Hornshøj, Henrik and Jeon, Jin-Tae and Jern, Patric and Jones, Matthew and Jurka, Jerzy and Kanamori, Hiroyuki and Kapetanovic, Ronan and Kim, Jaebum and Kim, Jae-Hwan and Kim, Kyu-Won and Kim, Tae-Hun and Larson, Greger and Lee, Kyooyeol and Lee, Kyung-Tai and Leggett, Richard and Lewin, Harris A. and Li, Yingrui and Liu, Wansheng and Loveland, Jane E. and Lu, Yao and Lunney, Joan K. and Ma, Jian and Madsen, Ole and Mann, Katherine and Matthews, Lucy and McLaren, Stuart R. and Morozumi, Takeya and Murtaugh, Michael P. and Narayan, Jitendra and Truong Nguyen, Dinh and Ni, Peixiang and Oh, Song-Jung and Onteru, Suneel and Panitz, Frank and Park, Eung-Woo and Park, Hong-Seog and Pascal, Geraldine and Paudel, Yogesh and Perez-Enciso, Miguel and Ramirez-Gonzalez, Ricardo and Reecy, James M. and Rodriguez-Zas, Sandra and Rohrer, Gary A. and Rund, Lauretta and Sang, Yongming and Schachtschneider, Kyle and Schraiber, Joshua G. and Schwartz, John and Scobie, Linda and Scott, Carol and Searle, Stephen and Servin, Bertrand and Southey, Bruce R. and Sperber, Goran and Stadler, Peter and Sweedler, Jonathan V. and Tafer, Hakim and Thomsen, Bo and Wali, Rashmi and Wang, Jian and Wang, Jun and White, Simon and Xu, Xun and Yerle, Martine and Zhang, Guojie and Zhang, Jianguo and Zhang, Jie and Zhao, Shuhong and Rogers, Jane and Churcher, Carol and Schook, Lawrence B. (2012) Analyses of pig genomes provide insight into porcine demography and evolution. Nature, 491 (7424). pp. 393-398. ISSN 0028-0836. (doi:https://doi.org/10.1038/nature11622) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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Official URL
http://dx.doi.org/10.1038/nature11622

Abstract

For 10,000 years pigs and humans have shared a close and complex relationship. From domestication to modern breeding practices, humans have shaped the genomes of domestic pigs. Here we present the assembly and analysis of the genome sequence of a female domestic Duroc pig (Sus scrofa) and a comparison with the genomes of wild and domestic pigs from Europe and Asia. Wild pigs emerged in South East Asia and subsequently spread across Eurasia. Our results reveal a deep phylogenetic split between European and Asian wild boars ~1 million years ago, and a selective sweep analysis indicates selection on genes involved in RNA processing and regulation. Genes associated with immune response and olfaction exhibit fast evolution. Pigs have the largest repertoire of functional olfactory receptor genes, reflecting the importance of smell in this scavenging animal. The pig genome sequence provides an important resource for further improvements of this important livestock species, and our identification of many putative disease-causing variants extends the potential of the pig as a biomedical model.

Item Type: Article
Subjects: Q Science
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Sue Davies
Date Deposited: 21 May 2014 11:08 UTC
Last Modified: 15 Jul 2014 15:35 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/41104 (The current URI for this page, for reference purposes)
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