Groenen, Martien A. M., Archibald, Alan L., Uenishi, Hirohide, Tuggle, Christopher K., Takeuchi, Yasuhiro, Rothschild, Max F., Rogel-Gaillard, Claire, Park, Chankyu, Milan, Denis, Megens, Hendrik-Jan, and others. (2012) Analyses of pig genomes provide insight into porcine demography and evolution. Nature, 491 (7424). pp. 393-398. ISSN 0028-0836. (doi:10.1038/nature11622) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:41104)
| The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. | |
| Official URL: http://dx.doi.org/10.1038/nature11622 |
Abstract
For 10,000?years pigs and humans have shared a close and complex relationship. From domestication to modern breeding practices, humans have shaped the genomes of domestic pigs. Here we present the assembly and analysis of the genome sequence of a female domestic Duroc pig (Sus scrofa) and a comparison with the genomes of wild and domestic pigs from Europe and Asia. Wild pigs emerged in South East Asia and subsequently spread across Eurasia. Our results reveal a deep phylogenetic split between European and Asian wild boars ~1 million years ago, and a selective sweep analysis indicates selection on genes involved in RNA processing and regulation. Genes associated with immune response and olfaction exhibit fast evolution. Pigs have the largest repertoire of functional olfactory receptor genes, reflecting the importance of smell in this scavenging animal. The pig genome sequence provides an important resource for further improvements of this important livestock species, and our identification of many putative disease-causing variants extends the potential of the pig as a biomedical model.
| Item Type: | Article |
|---|---|
| DOI/Identification number: | 10.1038/nature11622 |
| Uncontrolled keywords: | Genome evolution; Sequencing |
| Subjects: | Q Science |
| Divisions: | Divisions > Division of Natural Sciences > Biosciences |
| Depositing User: | Susan Davies |
| Date Deposited: | 21 May 2014 11:08 UTC |
| Last Modified: | 05 Nov 2024 10:25 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/41104 (The current URI for this page, for reference purposes) |
University of Kent Author Information
Griffin, Darren K..
| Creator's ORCID: |
 https://orcid.org/0000-0001-7595-3226
|
|---|---|
| CReDIT Contributor Roles: |
- Export to:
- RefWorks
- EPrints3 XML
- BibTeX
- CSV
- Depositors only (login required):
Altmetric
Altmetric
