Huang, Yinhua, Li, Yingrui, Burt, David W., Chen, Hualan, Zhang, Yong, Qian, Wubin, Kim, Heebal, Gan, Shangquan, Zhao, Yiqiang, Li, Jianwen, and others. (2013) The duck genome and transcriptome provide insight into an avian influenza virus reservoir species. Nature Genetics, 45 (7). pp. 776-783. ISSN 1061-4036. (doi:10.1038/ng.2657) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:41101)
| The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication) | |
| Official URL: http://dx.doi.org/10.1038/ng.2657 |
Abstract
The duck (Anas platyrhynchos) is one of the principal natural hosts of influenza A viruses. We present the duck genome sequence and perform deep transcriptome analyses to investigate immune-related genes. Our data indicate that the duck possesses a contractive immune gene repertoire, as in chicken and zebra finch, and this repertoire has been shaped through lineage-specific duplications. We identify genes that are responsive to influenza A viruses using the lung transcriptomes of control ducks and ones that were infected with either a highly pathogenic (A/duck/Hubei/49/05) or a weakly pathogenic (A/goose/Hubei/65/05) H5N1 virus. Further, we show how the duck's defense mechanisms against influenza infection have been optimized through the diversification of its ?-defensin and butyrophilin-like repertoires. These analyses, in combination with the genomic and transcriptomic data, provide a resource for characterizing the interaction between host and influenza viruses.
| Item Type: | Article |
|---|---|
| DOI/Identification number: | 10.1038/ng.2657 |
| Subjects: | Q Science |
| Divisions: | Divisions > Division of Natural Sciences > Biosciences |
| Depositing User: | Susan Davies |
| Date Deposited: | 21 May 2014 10:43 UTC |
| Last Modified: | 23 Jan 2020 04:08 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/41101 (The current URI for this page, for reference purposes) |
University of Kent Author Information
Griffin, Darren K..
| Creator's ORCID: |
 https://orcid.org/0000-0001-7595-3226
|
|---|---|
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