Heparin-binding epidermal growth factor and its receptor ErbB4 mediate implantation of the human blastocyst

Chobotova, Katya and Spyropoulou, Isabella and Carver, Janet and Manek, Sanjiv and Heath, John K. and Gullick, William J. and Barlow, David and Sargent, Ian L. and Mardon, Helen J. (2002) Heparin-binding epidermal growth factor and its receptor ErbB4 mediate implantation of the human blastocyst. Mechanisms of Development, 119 (2). pp. 137-144. ISSN 0925-4773 . (doi:https://doi.org/10.1016/S0925-4773(02)00342-8) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided)

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The mechanisms that mediate implantation of the human embryo remain poorly understood and represent a fundamental problem in reproductive biology. Candidate molecules that mediate and facilitate implantation have been identified in animal studies, and include heparin binding epidermal growth factor. Here we demonstrate a potential function for the transmembrane form of heparin-binding epidermal growth factor in mediating blastocyst attachment to the endometrium, in two different novel in vitro models for human implantation. Furthermore, we demonstrate specific localisation of the heparin-binding epidermal growth factor receptor ErbB4, on the surface of the trophectoderm in peri-implantation human blastocysts. Our data lead the way for further dissection of the molecular mechanisms of implantation of the human embryo, and have implications for infertility, in vitro fertilization and contraception.

Item Type: Article
Uncontrolled keywords: Heparin-binding epidermal growth factor; ErbB4; Implantation
Subjects: Q Science
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculties > Sciences > School of Biosciences > Biomedical Research Group
Depositing User: Bill Gullick
Date Deposited: 12 Jun 2008 09:21 UTC
Last Modified: 21 May 2014 13:23 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/3989 (The current URI for this page, for reference purposes)
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