Heparin-binding epidermal growth factor and its receptor ErbB4 mediate implantation of the human blastocyst

Chobotova, Katya, Spyropoulou, Isabella, Carver, Janet, Manek, Sanjiv, Heath, John K., Gullick, William J., Barlow, David, Sargent, Ian L., Mardon, Helen J. (2002) Heparin-binding epidermal growth factor and its receptor ErbB4 mediate implantation of the human blastocyst. Mechanisms of Development, 119 (2). pp. 137-144. ISSN 0925-4773. (doi:10.1016/S0925-4773(02)00342-8) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:3989)

PDF (The Human Blastocyst) Language: English Restricted to Repository staff only

Official URL: http://dx.doi.org/10.1016/S0925-4773(02)00342-8

Abstract

The mechanisms that mediate implantation of the human embryo remain poorly understood and represent a fundamental problem in reproductive biology. Candidate molecules that mediate and facilitate implantation have been identified in animal studies, and include heparin binding epidermal growth factor. Here we demonstrate a potential function for the transmembrane form of heparin-binding epidermal growth factor in mediating blastocyst attachment to the endometrium, in two different novel in vitro models for human implantation. Furthermore, we demonstrate specific localisation of the heparin-binding epidermal growth factor receptor ErbB4, on the surface of the trophectoderm in peri-implantation human blastocysts. Our data lead the way for further dissection of the molecular mechanisms of implantation of the human embryo, and have implications for infertility, in vitro fertilization and contraception.

Item Type:	Article
DOI/Identification number:	10.1016/S0925-4773(02)00342-8
Uncontrolled keywords:	Heparin-binding epidermal growth factor; ErbB4; Implantation
Subjects:	Q Science R Medicine > RC Internal medicine > RC254 Neoplasms. Tumors. Oncology
Divisions:	Divisions > Division of Natural Sciences > Biosciences
Depositing User:	William Gullick
Date Deposited:	12 Jun 2008 09:21 UTC
Last Modified:	05 Nov 2024 09:35 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/3989 (The current URI for this page, for reference purposes)

University of Kent Author Information

Gullick, William J..

Creator's ORCID:
CReDIT Contributor Roles:

Depositors only (login required):

Altmetric

Download Statistics

Total unique views for this document in KAR since July 2020. For more details click on the image.