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On reassessment of the chicken TGFB4 gene as TGFB1

Halper, Jaroslava, Burt, David W, Romanov, Michael N (2004) On reassessment of the chicken TGFB4 gene as TGFB1. Growth Factors, 22 (2). pp. 121-122. ISSN 0897-7194. (doi:10.1080/08977190410001712878) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1080/08977190410001712878

Abstract

Three TGFB isoforms, TGFB1-3, are present in mammalian cells. The presence of four TGFB isoforms has been reported in avian species, though the sequence of TGFB4 was not conclusively determined. Our previously published data show that TGFB4 is actually the chicken ortholog of TGFB1. We mapped TGFB1 but not TGFB4 to linkage group E25C31 on GGA32 next to RYR1 forming a conserved segment with human chromosome HSA19q13.1-q13.2 and, therefore, being definitely the ortholog of human TGFB1. We, therefore, suggest that what was once called chicken "TGFB4" is actually TGFB1. Thus, in the evolutionary lineages of birds and mammals there are only three TGFB isoforms.

Item Type: Article
DOI/Identification number: 10.1080/08977190410001712878
Uncontrolled keywords: transforming growth factor-beta-1; deoxyribonucleic-acid cloning; messenger ribonucleic-acid; embryo chondrocytes; expression
Subjects: Q Science > QH Natural history > QH426 Genetics
Divisions: Faculties > Sciences > School of Biosciences > Biomedical Research Group
Depositing User: M. Romanov
Date Deposited: 12 Dec 2013 17:13 UTC
Last Modified: 29 May 2019 11:40 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/37559 (The current URI for this page, for reference purposes)
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