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On reassessment of the chicken TGFB4 gene as TGFB1

Halper, Jaroslava, Burt, David W., Romanov, Michael N (2004) On reassessment of the chicken TGFB4 gene as TGFB1. Growth Factors, 22 (2). pp. 121-122. ISSN 0897-7194. (doi:10.1080/08977190410001712878) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:37559)

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Three TGFB isoforms, TGFB1-3, are present in mammalian cells. The presence of four TGFB isoforms has been reported in avian species, though the sequence of TGFB4 was not conclusively determined. Our previously published data show that TGFB4 is actually the chicken ortholog of TGFB1. We mapped TGFB1 but not TGFB4 to linkage group E25C31 on GGA32 next to RYR1 forming a conserved segment with human chromosome HSA19q13.1-q13.2 and, therefore, being definitely the ortholog of human TGFB1. We, therefore, suggest that what was once called chicken "TGFB4" is actually TGFB1. Thus, in the evolutionary lineages of birds and mammals there are only three TGFB isoforms.

Item Type: Article
DOI/Identification number: 10.1080/08977190410001712878
Uncontrolled keywords: transforming growth factor-beta-1; deoxyribonucleic-acid cloning; messenger ribonucleic-acid; embryo chondrocytes; expression
Subjects: Q Science > QD Chemistry > QD431 Organic Chemistry- Biochemistry- Proteins, peptides, amino acids
Q Science > QH Natural history > QH426 Genetics
Q Science > QH Natural history > QH581.2 Cell Biology
Divisions: Divisions > Division of Natural Sciences > Biosciences
Signature Themes: Food Systems, Natural Resources and Environment
Depositing User: Mike Romanov
Date Deposited: 12 Dec 2013 17:13 UTC
Last Modified: 08 Sep 2023 15:15 UTC
Resource URI: (The current URI for this page, for reference purposes)

University of Kent Author Information

Romanov, Michael N.

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