Halper, Jaroslava, Burt, David W., Romanov, Michael N (2004) On reassessment of the chicken TGFB4 gene as TGFB1. Growth Factors, 22 (2). pp. 121-122. ISSN 0897-7194. (doi:10.1080/08977190410001712878) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:37559)
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Official URL: https://doi.org/10.1080/08977190410001712878 |
Abstract
Three TGFB isoforms, TGFB1-3, are present in mammalian cells. The presence of four TGFB isoforms has been reported in avian species, though the sequence of TGFB4 was not conclusively determined. Our previously published data show that TGFB4 is actually the chicken ortholog of TGFB1. We mapped TGFB1 but not TGFB4 to linkage group E25C31 on GGA32 next to RYR1 forming a conserved segment with human chromosome HSA19q13.1-q13.2 and, therefore, being definitely the ortholog of human TGFB1. We, therefore, suggest that what was once called chicken "TGFB4" is actually TGFB1. Thus, in the evolutionary lineages of birds and mammals there are only three TGFB isoforms.
Item Type: | Article |
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DOI/Identification number: | 10.1080/08977190410001712878 |
Uncontrolled keywords: | transforming growth factor-beta-1; deoxyribonucleic-acid cloning; messenger ribonucleic-acid; embryo chondrocytes; expression |
Subjects: |
Q Science > QD Chemistry > QD431 Organic Chemistry- Biochemistry- Proteins, peptides, amino acids Q Science > QH Natural history > QH426 Genetics Q Science > QH Natural history > QH581.2 Cell Biology |
Divisions: | Divisions > Division of Natural Sciences > Biosciences |
Signature Themes: | Food Systems, Natural Resources and Environment |
Depositing User: | Mike Romanov |
Date Deposited: | 12 Dec 2013 17:13 UTC |
Last Modified: | 08 Sep 2023 15:15 UTC |
Resource URI: | https://kar.kent.ac.uk/id/eprint/37559 (The current URI for this page, for reference purposes) |
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