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Libraries of large-insert genomic clones as a tool for molecular cytogenetic analysis of avian genome

Sazanov, Alexei A, Romanov, Michael N, Smirnov, Alexandr F (2005) Libraries of large-insert genomic clones as a tool for molecular cytogenetic analysis of avian genome. Russian Journal of Genetics, 41 (5). pp. 461-467. ISSN 1022-7954. E-ISSN 1608-3369. (doi:10.1007/s11177-005-0111-z) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:37554)

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Abstract

Integration of molecular and cytegenetic levels of investigation results in complex understanding of structural and functional genome organization. Gridded libraries of large-insert genomic clones represent a powerful tool of the genome analysis. Their utilization provides coordination of data on molecular organization of nucleic acids with cytogenetic data on the chromosome structure. These libraries played an important role in sequencing of genomes of human, mouse, and other organisms as an instrument linking molecular biological and cytogenetic data via construction of contigs and their localization on the chromosomes. They also enabled analysis of orthology between the mammalian genomes. The existing avian libraries fit molecular cytogenetic analysis of the class Aves genome, and can be successfully used for the isolation and characterization of large genomic fragments. This provides utilization of these libraries not only for the chromosome mapping, but also for positional cloning and search for candidate genes for quantitative traits.

Item Type: Article
DOI/Identification number: 10.1007/s11177-005-0111-z
Uncontrolled keywords: marker assisted selection; quantitative trait loci; radiation hybrid map; chicken genome; physical map; chromosomal localization; conserved synteny; BAC contig Nucleic Acid; Candidate Gene; Quantitative Trait; Chromosome Mapping; Genome Analysis
Subjects: Q Science > QH Natural history > QH426 Genetics
Q Science > QL Zoology
S Agriculture > SF Animal culture
Divisions: Divisions > Division of Natural Sciences > Biosciences
Signature Themes: Food Systems, Natural Resources and Environment
Depositing User: Mike Romanov
Date Deposited: 12 Dec 2013 17:23 UTC
Last Modified: 16 Nov 2021 10:14 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/37554 (The current URI for this page, for reference purposes)
Romanov, Michael N: https://orcid.org/0000-0003-3584-4644
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