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Strategies to assess structural variation in the chicken genome and its associations with biodiversity and biological performance

Soller, M, Weigend, S, Romanov, Michael N, Dekkers, J C M, Lamont, S J (2006) Strategies to assess structural variation in the chicken genome and its associations with biodiversity and biological performance. Poultry Science, 85 (12). pp. 2061-2078. ISSN 0032-5791. (doi:10.1093/ps/85.12.2061) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided)

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Abstract

A primary goal in the assessment of structural variation in the avian genome is to understand the relationship of this variation with biodiversity and with biological performance. To develop such knowledge, certain essential tools are needed. One set of tools includes the laboratory techniques used to assess molecular genetic variation. The current time is a transitional one for this field, in that the recently sequenced chicken genome will add significantly to the portfolio of existing methods used to identify molecular markers. To most efficiently discover marker-trait associations, the experimental mapping populations must be appropriately designed and the relevant statistical analyses applied. This paper reviews methods for assessment of molecular markers in poultry and their use in the characterization of avian biodiversity and in studies to identify marker associations with biological traits, including important considerations of population structure and statistical analysis.

Item Type: Article
DOI/Identification number: 10.1093/ps/85.12.2061
Uncontrolled keywords: structural variation; genome; biodiversity; quantitative trait gene; candidate gene
Subjects: Q Science > QH Natural history > QH426 Genetics
Divisions: Faculties > Sciences > School of Biosciences > Biomedical Research Group
Depositing User: M. Romanov
Date Deposited: 12 Dec 2013 16:34 UTC
Last Modified: 29 May 2019 11:39 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/37546 (The current URI for this page, for reference purposes)
Romanov, Michael N: https://orcid.org/0000-0003-3584-4644
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