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Sulfate-reducing bacteria reveal a new branch of tetrapyrrole metabolism

Lobo, Susana A.L. and Warren, Martin J. and Saraiva, Lígia M. (2012) Sulfate-reducing bacteria reveal a new branch of tetrapyrrole metabolism. In: Advances in Microbial Physiology. Elsevier Ltd, pp. 267-295. ISBN 978-0-12-394423-8. (doi:10.1016/B978-0-12-394423-8.00007-X) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:34203)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL:
http://dx.doi.org/10.1016/B978-0-12-394423-8.00007...

Abstract

Sulfate-reducing microorganisms are a diverse group of bacteria and archaea that occupy important environmental niches and have potential for significant biotechnological impact. Desulfovibrio, the most studied genus among the sulfate-reducing microorganisms, contains proteins with a wide variety of tetrapyrrole-derived cofactors, including some unique derivatives such as uroporphyrin I and coproporphyrin III. Herein, we review tetrapyrrole metabolism in Desulfovibrio spp., including the production of sirohaem and cobalamin, and compare and contrast the biochemical properties of the enzymes involved in these biosynthetic pathways. Furthermore, we describe a novel pathway used by Desulfovibrio to synthesize haem b, which provides a previously unrecognized link between haem, sirohaem, and haem d(1). Finally, the organization and regulation of genes involved in the tetrapyrrole biosynthetic pathway is discussed.

Item Type: Book section
DOI/Identification number: 10.1016/B978-0-12-394423-8.00007-X
Uncontrolled keywords: haem; sirohaem; cobalamin; biosynthesis; pathway; Desulfovibrio
Subjects: Q Science
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: Lin Riches
Date Deposited: 14 Jun 2013 09:47 UTC
Last Modified: 16 Nov 2021 10:11 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/34203 (The current URI for this page, for reference purposes)

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