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Simple and efficient method for the detection of diethylenetriaminepentaacetic acid.

Weber, Carolin, Michaelis, Martin, Vogel, Jens-Uwe, Cinatl, Jindrich, Kreuter, Jörg, Langer, Klaus (1999) Simple and efficient method for the detection of diethylenetriaminepentaacetic acid. Journal of Chromatography B: Biomedical Sciences and Applications, 736 (1-2). pp. 299-303. ISSN 1387-2273. (doi:10.1016/S0378-4347(99)00456-9) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1016/S0378-4347(99)00456-9

Abstract

Diethylenetriaminepentaacetic acid (DTPA) is a commonly used chelating agent. Its antiviral, antibacterial and immunomodulatory effects are well documented. DTPA forms a highly stable complex with lead (II) with an increased absorption coefficient and a bathochromic shift of the absorption maximum compared to pure DTPA. Based on this complex a high-performance liquid chromatographic method for the quantitative detection of DTPA in biological fluids was developed. A calibration curve was prepared and linearity was shown in the concentration range between 10 mg l(-1) and 1000 mg l(-1) DTPA. The recovery in water and in human plasma showed the method to be suitable for routine use.

Item Type: Article
DOI/Identification number: 10.1016/S0378-4347(99)00456-9
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Martin Michaelis
Date Deposited: 05 Jun 2013 19:56 UTC
Last Modified: 29 May 2019 10:15 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/34132 (The current URI for this page, for reference purposes)
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