Weber, Carolin, Michaelis, Martin, Vogel, Jens-Uwe, Cinatl, Jindrich, Kreuter, Jörg, Langer, Klaus (1999) Simple and efficient method for the detection of diethylenetriaminepentaacetic acid. Journal of Chromatography B: Biomedical Sciences and Applications, 736 (1-2). pp. 299-303. ISSN 1387-2273. (doi:10.1016/S0378-4347(99)00456-9) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:34132)
| The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. | |
| Official URL: http://dx.doi.org/10.1016/S0378-4347(99)00456-9 |
Abstract
Diethylenetriaminepentaacetic acid (DTPA) is a commonly used chelating agent. Its antiviral, antibacterial and immunomodulatory effects are well documented. DTPA forms a highly stable complex with lead (II) with an increased absorption coefficient and a bathochromic shift of the absorption maximum compared to pure DTPA. Based on this complex a high-performance liquid chromatographic method for the quantitative detection of DTPA in biological fluids was developed. A calibration curve was prepared and linearity was shown in the concentration range between 10 mg l(-1) and 1000 mg l(-1) DTPA. The recovery in water and in human plasma showed the method to be suitable for routine use.
| Item Type: | Article |
|---|---|
| DOI/Identification number: | 10.1016/S0378-4347(99)00456-9 |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Divisions > Division of Natural Sciences > Biosciences |
| Depositing User: | Martin Michaelis |
| Date Deposited: | 05 Jun 2013 19:56 UTC |
| Last Modified: | 05 Nov 2024 10:17 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/34132 (The current URI for this page, for reference purposes) |
University of Kent Author Information
Michaelis, Martin.
| Creator's ORCID: |
 https://orcid.org/0000-0002-5710-5888
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