Infection of cultured intestinal epithelial cells with severe acute respiratory syndrome coronavirus.

Cinatl, Jindrich and Hoever, Gerold and Morgenstern, Birgit and Preiser, Wolfgang and Vogel, Jens-Uwe and Hofmann, W-K and Bauer, Gabriele and Michaelis, Martin and Rabenau, Holger F and Doerr, Hans Wilhelm (2004) Infection of cultured intestinal epithelial cells with severe acute respiratory syndrome coronavirus. Cellular and Molecular Life Sciences, 61 (16). pp. 2100-12. ISSN 1420-9071. (doi:https://doi.org/10.1007/s00018-004-4222-9) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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Official URL
http://dx.doi.org10.1007/s00018-004-4222-9

Abstract

To identify a model for the study of intestinal pathogenesis of severe acute respiratory syndrome (SARS) we tested the sensitivity of six human intestinal epithelial cell lines to infection with SARS coronavirus (SARS-CoV). In permissive cell lines, effects of SARS-CoV on cellular gene expression were analysed using high-density oligonucleotide arrays. Caco-2 and CL-14 cell lines were found to be highly permissive to SARS-CoV, due to the presence of angiotensin-converting enzyme 2 as a functional receptor. In both cell lines, SARS-CoV infection deregulated expression of cellular genes which may be important for the intestinal pathogenesis of SARS.

Item Type: Article
Subjects: Q Science > QR Microbiology > QR355 Virology
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Martin Michaelis
Date Deposited: 05 Jun 2013 20:20 UTC
Last Modified: 19 Jun 2014 13:59 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/34118 (The current URI for this page, for reference purposes)
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