Cinatl, Jindrich, Hoever, Gerold, Morgenstern, Birgit, Preiser, Wolfgang, Vogel, Jens-Uwe, Hofmann, W-K, Bauer, Gabriele, Michaelis, Martin, Rabenau, Holger F, Doerr, Hans Wilhelm and others. (2004) Infection of cultured intestinal epithelial cells with severe acute respiratory syndrome coronavirus. Cellular and Molecular Life Sciences, 61 (16). pp. 2100-12. ISSN 1420-9071. (doi:10.1007/s00018-004-4222-9) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:34118)
| The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. | |
| Official URL: http://dx.doi.org10.1007/s00018-004-4222-9 |
|
Abstract
To identify a model for the study of intestinal pathogenesis of severe acute respiratory syndrome (SARS) we tested the sensitivity of six human intestinal epithelial cell lines to infection with SARS coronavirus (SARS-CoV). In permissive cell lines, effects of SARS-CoV on cellular gene expression were analysed using high-density oligonucleotide arrays. Caco-2 and CL-14 cell lines were found to be highly permissive to SARS-CoV, due to the presence of angiotensin-converting enzyme 2 as a functional receptor. In both cell lines, SARS-CoV infection deregulated expression of cellular genes which may be important for the intestinal pathogenesis of SARS.
| Item Type: | Article |
|---|---|
| DOI/Identification number: | 10.1007/s00018-004-4222-9 |
| Subjects: | Q Science > QR Microbiology > QR355 Virology |
| Institutional Unit: | Schools > School of Natural Sciences > Biosciences |
| Former Institutional Unit: |
Divisions > Division of Natural Sciences > Biosciences
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| Depositing User: | Martin Michaelis |
| Date Deposited: | 05 Jun 2013 20:20 UTC |
| Last Modified: | 20 May 2025 09:17 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/34118 (The current URI for this page, for reference purposes) |
University of Kent Author Information
Michaelis, Martin.
| Creator's ORCID: |
 https://orcid.org/0000-0002-5710-5888
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