Antiviral activity of glycyrrhizic acid derivatives against SARS-coronavirus.

Hoever, Gerold and Baltina, Lidia and Michaelis, Martin and Kondratenko, Rimma and Baltina, Lia and Tolstikov, Genrich A and Doerr, Hans Wilhelm and Cinatl, Jindrich (2005) Antiviral activity of glycyrrhizic acid derivatives against SARS-coronavirus. Journal of Medicinal Chemistry, 48 (4). pp. 1256-9. ISSN 0022-2623. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)

Abstract

Glycyrrhizin (GL) was shown to inhibit SARS-coronavirus (SARS-CoV) replication in vitro. Here the anti-SARS-CoV activity of 15 GL derivatives was tested. The introduction of 2-acetamido-beta-d-glucopyranosylamine into the glycoside chain of GL resulted in 10-fold increased anti-SARS-CoV activity compared to GL. Amides of GL and conjugates of GL with two amino acid residues and a free 30-COOH function presented up to 70-fold increased activity against SARS-CoV but also increased cytotoxicity resulting in decreased selectivity index.

Item Type: Article
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Martin Michaelis
Date Deposited: 05 Jun 2013 20:32 UTC
Last Modified: 01 Jul 2014 15:46 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/34111 (The current URI for this page, for reference purposes)
  • Depositors only (login required):