Hoever, Gerold, Baltina, Lidia, Michaelis, Martin, Kondratenko, Rimma, Baltina, Lia, Tolstikov, Genrich A, Doerr, Hans Wilhelm, Cinatl, Jindrich (2005) Antiviral activity of glycyrrhizic acid derivatives against SARS-coronavirus. Journal of Medicinal Chemistry, 48 (4). pp. 1256-9. ISSN 0022-2623. (doi:10.1021/jm0493008) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:34111)
| The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. | |
| Official URL: https://doi.org/10.1021/jm0493008 |
|
Abstract
Glycyrrhizin (GL) was shown to inhibit SARS-coronavirus (SARS-CoV) replication in vitro. Here the anti-SARS-CoV activity of 15 GL derivatives was tested. The introduction of 2-acetamido-beta-d-glucopyranosylamine into the glycoside chain of GL resulted in 10-fold increased anti-SARS-CoV activity compared to GL. Amides of GL and conjugates of GL with two amino acid residues and a free 30-COOH function presented up to 70-fold increased activity against SARS-CoV but also increased cytotoxicity resulting in decreased selectivity index.
| Item Type: | Article |
|---|---|
| DOI/Identification number: | 10.1021/jm0493008 |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology |
| Institutional Unit: | Schools > School of Natural Sciences > Biosciences |
| Former Institutional Unit: |
Divisions > Division of Natural Sciences > Biosciences
|
| Depositing User: | Martin Michaelis |
| Date Deposited: | 05 Jun 2013 20:32 UTC |
| Last Modified: | 20 May 2025 09:17 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/34111 (The current URI for this page, for reference purposes) |
University of Kent Author Information
Michaelis, Martin.
| Creator's ORCID: |
 https://orcid.org/0000-0002-5710-5888
|
|---|---|
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