Michaelis, Martin, Suhan, Tatyana, Reinisch, Alexander, Reisenauer, Agnes, Fleckenstein, Corinna, Eikel, Daniel, Gümbel, Hermann, Doerr, Hans Wilhelm, Nau, Heinz, Cinatl, Jindrich and others. (2005) Increased replication of human cytomegalovirus in retinal pigment epithelial cells by valproic acid depends on histone deacetylase inhibition. Investigative Ophthalmology and Visual Science, 46 (9). pp. 3451-7. ISSN 0146-0404. (doi:10.1167/iovs.05-0369) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:34108)
| The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. | |
| Official URL: https://doi.org/10.1167/iovs.05-0369 |
Abstract
The data demonstrate that VPA stimulates HCMV replication by HDAC inhibition independent of Erk 1/2 phosphorylation in therapeutic concentrations in RPE cells. Therefore, patients at risk of HCMV retinitis who are treated with VPA or other HDAC inhibitors should be carefully monitored.
| Item Type: | Article |
|---|---|
| DOI/Identification number: | 10.1167/iovs.05-0369 |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Divisions > Division of Natural Sciences > Biosciences |
| Depositing User: | Martin Michaelis |
| Date Deposited: | 05 Jun 2013 20:39 UTC |
| Last Modified: | 09 Mar 2023 11:32 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/34108 (The current URI for this page, for reference purposes) |
University of Kent Author Information
Michaelis, Martin.
| Creator's ORCID: |
 https://orcid.org/0000-0002-5710-5888
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|---|---|
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