Zhang, Han-Zhong, Zhang, Hong, Kemnitzer, William, Tseng, Ben, Cinatl, Jindrich, Michaelis, Martin, Doerr, Hans Wilhelm, Cai, Sui Xiong (2006) Design and synthesis of dipeptidyl glutaminyl fluoromethyl ketones as potent severe acute respiratory syndrome coronovirus (SARS-CoV) inhibitors. Journal of Medicinal Chemistry, 49 (3). pp. 1198-201. ISSN 0022-2623. (doi:10.1021/jm0507678) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:34100)
| The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. | |
| Official URL: https://doi.org/10.1021/jm0507678 |
Abstract
This paper describes the design and synthesis of dipeptidyl N,N-dimethyl glutaminyl fluoromethyl ketones (fmk) as severe acute respiratory syndrome coronovirus (SARS-CoV) inhibitors. The compounds were tested against SARS-CoV-induced cell death in Vero or CaCo2 cells as a measurement of the inhibiting effects of the compounds on the replication of the virus. Z-Leu-Gln(NMe(2))-fmk (6a) was found to be a potent inhibitor with low toxicity in cells, protecting cells with an EC(50) value of 2.5 microM and exhibiting a selectivity index of >40.
| Item Type: | Article |
|---|---|
| DOI/Identification number: | 10.1021/jm0507678 |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Divisions > Division of Natural Sciences > Biosciences |
| Depositing User: | Martin Michaelis |
| Date Deposited: | 05 Jun 2013 20:52 UTC |
| Last Modified: | 09 Mar 2023 11:32 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/34100 (The current URI for this page, for reference purposes) |
University of Kent Author Information
Michaelis, Martin.
| Creator's ORCID: |
 https://orcid.org/0000-0002-5710-5888
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