Krenn, Brigitte M, Egorov, Andrej, Romanovskaya-Romanko, Ekaterina, Wolschek, Markus, Nakowitsch, Sabine, Ruthsatz, Tanja, Kiefmann, Bettina, Morokutti, Alexander, Humer, Johannes, Geiler, Janina, and others. (2011) Single HA2 mutation increases the infectivity and immunogenicity of a live attenuated H5N1 intranasal influenza vaccine candidate lacking NS1. PLoS ONE, 6 (4). e18577. ISSN 1932-6203. (doi:10.1371/journal.pone.0018577) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:34057)
| The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. | |
| Official URL: https://doi.org/10.1371/journal.pone.0018577 |
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Abstract
Our finding suggests that an efficient intranasal vaccination with a live attenuated H5N1 virus may require a certain level of pH and temperature stability of HA in order to achieve an optimal virus uptake by the nasal epithelial cells and induce a sufficient immune response. The pH of the activation of the H5 HA protein may play a substantial role in the infectivity of HPAIVs for mammals.
| Item Type: | Article |
|---|---|
| DOI/Identification number: | 10.1371/journal.pone.0018577 |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology |
| Institutional Unit: | Schools > School of Natural Sciences > Biosciences |
| Former Institutional Unit: |
Divisions > Division of Natural Sciences > Biosciences
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| Depositing User: | Martin Michaelis |
| Date Deposited: | 05 Jun 2013 16:46 UTC |
| Last Modified: | 20 May 2025 09:17 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/34057 (The current URI for this page, for reference purposes) |
University of Kent Author Information
Michaelis, Martin.
| Creator's ORCID: |
 https://orcid.org/0000-0002-5710-5888
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