Mahallawi, Waleed H, Kasbekar, Anand V, McCormick, Maxwell S, Hoschler, Katja, Temperton, Nigel J., Leong, Samuel C, Beer, Helen, Ferrara, Francesca, McNamara, Paul S, Zhang, Qibo and others. (2013) 2009 H1N1 infection primes for immunological memory in human nasal-associated lymphoid tissue that offers cross-reactive immunity to H1N1 and avian H5N1 viruses. Journal of Virology, . ISSN 0022-538X. E-ISSN 1098-5514. (doi:10.1128/JVI.03547-12) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:33367)
The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. | |
Official URL: http://dx.doi.org/10.1128/JVI.03547-12 |
Abstract
Influenza is a highly contagious mucosal infection in the respiratory tract. 2009 pandemic H1N1 (pH1N1) virus infection resulted in substantial morbidity and mortality in humans. Little is known on whether immunological memory develops following pH1N1 infection and whether it provides protection against other virus subtypes. Enzyme-linked immunosorbent spot assay was used to analyze hemagglutinin (HA)-specific memory B cell responses after virus antigen stimulation in nasal-associated lymphoid tissues (NALT) from children and adults. Individuals with serological evidence of previous exposure to pH1N1 showed significant cross-reactive HA-specific memory B responses to pH1N1, seasonal H1N1(sH1N1) and avian H5N1(aH5N1) viruses upon pH1N1 virus stimulation. pH1N1 virus antigen elicited stronger cross-reactive memory B cell responses than sH1N1 virus. Intriguingly, aH5N1 virus also activated cross-reactive memory responses to sH1N1 and pH1N1 HAs in those who had previous pH1N1 exposure, and that correlated well with the memory response stimulated by pH1N1 virus antigen. These memory B cell responses resulted in cross-reactive neutralizing antibodies against sH1N1, 1918 H1N1 and aH5N1viruses. 2009 pH1N1 infection appeared to have primed human host with B cell memory in NALT that offers cross-protective mucosal immunity against not only H1N1 but also aH5N1 viruses. These findings may have important implications to future vaccination strategies against influenza. It will be important to induce and/or enhance such cross-protective mucosal memory B cells.
Item Type: | Article |
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DOI/Identification number: | 10.1128/JVI.03547-12 |
Additional information: | Published online ahead of Print (March 2013) |
Subjects: | Q Science > QR Microbiology > QR355 Virology |
Divisions: | Divisions > Division of Natural Sciences > Medway School of Pharmacy |
Depositing User: | Nigel Temperton |
Date Deposited: | 09 Mar 2013 12:28 UTC |
Last Modified: | 05 Nov 2024 10:16 UTC |
Resource URI: | https://kar.kent.ac.uk/id/eprint/33367 (The current URI for this page, for reference purposes) |
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