Simulating complex intracellular processes using object-oriented computational modelling

Johnson, Colin G., Goldman, Jacki P., Gullick, William J. (2004) Simulating complex intracellular processes using object-oriented computational modelling. Progress in Biophysics and Molecular Biology, 86 (3). pp. 379-406. ISSN 0079-6107. (doi:10.1016/j.pbiomolbio.2003.11.001) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:33)

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Official URL: http://dx.doi.org/10.1016/j.pbiomolbio.2003.11.001

Abstract

The aim of this paper is to give an overview of computer modelling and simulation in cellular biology, in particular as applied to complex biochemical processes within the cell. This is illustrated by the use of the techniques of object-oriented modelling, where the computer is used to construct abstractions of objects in the domain being modelled, and these objects then interact within the computer to simulate the system and allow emergent properties to be observed. The paper also discusses the role of computer simulation in understanding complexity in biological systems, and the kinds of information which can be obtained about biology via simulation.

Item Type:	Article
DOI/Identification number:	10.1016/j.pbiomolbio.2003.11.001
Uncontrolled keywords:	Computational modelling; Object-oriented methods; Intracellular processes; Protein–protein interactions
Subjects:	Q Science R Medicine > RC Internal medicine > RC254 Neoplasms. Tumors. Oncology
Divisions:	Divisions > Division of Natural Sciences > Biosciences
Depositing User:	Susan Davies
Date Deposited:	19 Dec 2007 17:46 UTC
Last Modified:	05 Nov 2024 09:29 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/33 (The current URI for this page, for reference purposes)

University of Kent Author Information

Johnson, Colin G..

Creator's ORCID:	https://orcid.org/0000-0002-9236-6581
CReDIT Contributor Roles:

Gullick, William J..

Creator's ORCID:
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