Kinetic models of guanidine hydrochloride-induced curing of the yeast [PSI + ] prion

Palmer, Karen J., Ridout, Martin S., Morgan, Byron J. T. (2011) Kinetic models of guanidine hydrochloride-induced curing of the yeast [PSI + ] prion. Journal of Theoretical Biology, 274 (1). pp. 1-11. ISSN 0022-5193. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:32980)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.

Abstract

A population of [PSI + ] Saccharomyces cerevisiae cells can be cured of the [PSI + ] prion by the addition of

guanidine hydrochloride (GdnHCl). In this paper we extend existing nucleated polymerisation simulation

models to investigate the mechanisms that might underlie curing. Our results are consistent with the

belief that prions are dispersed through the cells at division following GdnHCl addition. A key feature of

the simulation model is that the probability that a polymer is transmitted from mother to daughter during

cell division is dependent upon the length of the polymer. The model is able to reproduce the essential

features of data from several different experimental protocols involving addition and removal of GdnHCl.

Item Type:	Article
Uncontrolled keywords:	Curing Guanidine hydrochloride Saccharomyces cerevisiae Yeast prion
Subjects:	Q Science > QA Mathematics (inc Computing science) > QA276 Mathematical statistics Q Science > QP Physiology (Living systems) > QP506 Molecular biology
Divisions:	Divisions > Division of Computing, Engineering and Mathematical Sciences > School of Mathematics, Statistics and Actuarial Science
Depositing User:	Byron Morgan
Date Deposited:	14 Jan 2013 17:50 UTC
Last Modified:	16 Nov 2021 10:10 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/32980 (The current URI for this page, for reference purposes)

University of Kent Author Information

Ridout, Martin S..

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Morgan, Byron J. T..

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