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Surface engineering of nanoparticles in suspension for particle based bio-sensing

Sen, Tapas, Bruce, Ian J. (2012) Surface engineering of nanoparticles in suspension for particle based bio-sensing. Scientific Reports, 2 . ISSN 2045-2322. (doi:10.1038/srep00564) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:32104)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL:
http://dx.doi.org/10.1038/srep00564

Abstract

Surface activation of nanoparticles in suspension using amino organosilane has been carried out via strict control of a particle surface ad-layer of water using a simple but efficient protocol ‘Tri-phasic Reverse Emulsion’ (TPRE). This approach produced thin and ordered layers of particle surface functional groups which allowed the efficient conjugation of biomolecules. When used in bio-sensing applications, the resultant conjugates were highly efficient in the hybrid capture of complementary oligonucleotides and the detection of food borne microorganism. TPRE overcomes a number of fundamental problems associated with the surface modification of particles in aqueous suspension viz. particle aggregation, density and organization of resultant surface functional groups by controlling surface condensation of the aminosilane. The approach has potential for application in areas as diverse as nanomedicine, to food technology and industrial catalysis.

Item Type: Article
DOI/Identification number: 10.1038/srep00564
Additional information: Article number: 564
Uncontrolled keywords: DNA; Nanobiotechnology; Surface patterning
Subjects: Q Science
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: Susan Davies
Date Deposited: 06 Nov 2012 16:51 UTC
Last Modified: 16 Nov 2021 10:09 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/32104 (The current URI for this page, for reference purposes)

University of Kent Author Information

Bruce, Ian J..

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