Enhanced drug targeting by attachment of an anti ?v integrin antibody to doxorubicin loaded human serum albumin nanoparticles

Wagner, Sylvia, Rothweiler, Florian, Anhorn, Marion G., Sauer, Daniel, Riemann, Iris, Weiss, Eike C., Katsen-Globa, Alisa, Michaelis, Martin, Cinatl, Jindrich, Schwartz, Daniel and others. (2010) Enhanced drug targeting by attachment of an anti ?v integrin antibody to doxorubicin loaded human serum albumin nanoparticles. Biomaterials, 31 (8). pp. 2388-2398. ISSN 0142-9612. (doi:10.1016/j.biomaterials.2009.11.093) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:31967)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL: http://dx.doi.org/10.1016/j.biomaterials.2009.11.0...

Abstract

Specific transport of anti-cancer drugs into tumor cells may result in increased therapeutic efficacy and decreased adverse events. Expression of ?v?3 integrin is enhanced in various types of cancer and monoclonal antibodies (mAbs) directed against ?v?3 integrins hold promise for anti-cancer therapy. DI17E6 is a monoclonal antibody directed against ?v integrins that inhibits growth of melanomas in vitro and in vivo and inhibits angiogenesis due to interference with ?v?3 integrins. Here, DI17E6 was covalently coupled to human serum albumin nanoparticles. Resulting nanoparticles specifically targeted ?v?3 integrin positive melanoma cells. Moreover, doxorubicin loaded DI17E6 nanoparticles showed increased cytotoxic activity in ?v?3-positive melanoma cells than the free drug. Therefore, DI17E6-coupled human serum albumin nanoparticles represent a potential delivery system for targeted drug transport into ?v?3-positive cells.

Item Type:	Article
DOI/Identification number:	10.1016/j.biomaterials.2009.11.093
Uncontrolled keywords:	Albumin; Chemotherapy; Drug delivery; ECM (extracellular matrix); Integrin; Nanoparticles
Subjects:	Q Science
Divisions:	Divisions > Division of Natural Sciences > Biosciences
Depositing User:	Susan Davies
Date Deposited:	24 Oct 2012 15:19 UTC
Last Modified:	16 Nov 2021 10:09 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/31967 (The current URI for this page, for reference purposes)

University of Kent Author Information

Michaelis, Martin.

Creator's ORCID:	https://orcid.org/0000-0002-5710-5888
CReDIT Contributor Roles:

Depositors only (login required):

Altmetric

Download Statistics

Total unique views for this document in KAR since July 2020. For more details click on the image.