Phillips, Chris, Roberts, Lee R., Schade, Markus, Bazin, Richard, Bent, Andrew, Davies, Nichola L., Moore, Rob, Pannifer, Andrew D., Pickford, Andrew R., Prior, Stephen H., and others. (2011) Design and Structure of Stapled Peptides Binding to Estrogen Receptors. Journal of the American Chemical Society, 133 (25). pp. 9696-9699. ISSN 0002-7863. (doi:10.1021/ja202946k) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:31351)
| The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. | |
| Official URL: http://dx.doi.org/10.1021/ja202946k |
Abstract
Synthetic peptides that specifically bind nuclear hormone receptors offer an alternative approach to small molecules for the modulation of receptor signaling and subsequent gene expression. Here we describe the design of a series of novel stapled peptides that bind the coactivator peptide site of estrogen receptors. Using a number of biophysical techniques, including crystal structure analysis of receptor–stapled peptide complexes, we describe in detail the molecular interactions and demonstrate that all-hydrocarbon staples modulate molecular recognition events. The findings have implications for the design of stapled peptides in general.
| Item Type: | Article |
|---|---|
| DOI/Identification number: | 10.1021/ja202946k |
| Subjects: | Q Science |
| Divisions: | Divisions > Division of Natural Sciences > Biosciences |
| Depositing User: | Susan Davies |
| Date Deposited: | 08 Oct 2012 10:58 UTC |
| Last Modified: | 05 Nov 2024 10:13 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/31351 (The current URI for this page, for reference purposes) |
- Export to:
- RefWorks
- EPrints3 XML
- BibTeX
- CSV
- Depositors only (login required):
Altmetric
Altmetric
