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Solubility of chlordiazepoxide,diazepam,and lorazepam in ethanol+water mixtures at 303.2 K

Jouyban, Abolghasem, Shokri, Javad, Barzegar-Jalali, Mohammad, Hassanzadeh, Davoud, Acree, William Eugene, Ghafourian, Taravat, Nokhodchi, Ali (2009) Solubility of chlordiazepoxide,diazepam,and lorazepam in ethanol+water mixtures at 303.2 K. Journal of Chemical and Engineering Data, 54 (7). pp. 2142-2145. ISSN 00219568 (ISSN). (doi:10.1021/je900200k) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1021/je900200k

Abstract

Experimental solubilities of three benzodiazepines (chlordiazepoxide, diazepam,and lorazepam) in ethanol+water mixtures at 303.2 K are reported.The solubility of drugs was increased with the addition of ethanol and reached the maximum value of a volume fraction of 90 % of ethanol.The Jouyban-Acree model was used to fit the experimental data,and the solubilities were reproduced using previously trained version of the Jouyban-Acree model and the solubility data in monosolvents in which the overall mean relative deviations (OMRDs) of the models were 8.6 %,21.9 % and 19.3 %,respectively,for the fitted model,the trained version for ethanol+water mixtures and generally trained version for various organic solvents+water mixtures. © 2009 American Chemical Society.

Item Type: Article
DOI/Identification number: 10.1021/je900200k
Additional information: Unmapped bibliographic data: PY - 2009/// [EPrints field already has value set] AD - Faculty of Pharmacy and Drug Applied Research Center, Biotechnology Research Center, Research Center for Pharmaceutical Nanotechnology, Tabriz 51664, Iran [Field not mapped to EPrints] AD - Faculty of Pharmacy and Drug Applied Research Center, Tabriz University(Medical Sciences)., Denton,Texas 76203-5070 [Field not mapped to EPrints] AD - Biotechnology Research Center, Tabriz University (Medical Sciences), Research Center for Pharmaceutical Nanotechnology, Denton,Texas 76203-5070 [Field not mapped to EPrints] AD - Department of Chemistry, University of North Texas, Denton,Texas 76203-5070 [Field not mapped to EPrints] AD - Medway School of Pharmacy, Universities of Kent and Greenwich, Kent ME4 4TB, United Kingdom [Field not mapped to EPrints] JA - J Chem Eng Data [Field not mapped to EPrints]
Uncontrolled keywords: Benzodiazepines, Experimental data, Jouyban-Acree model, Lorazepam, Maximum values, Relative deviations, Solubility data, Water mixture, Ethanol, Organic solvents, Ternary systems, Volume fraction, Solubility
Subjects: Q Science > QD Chemistry
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Taravat Ghafourian
Date Deposited: 29 Dec 2013 17:35 UTC
Last Modified: 29 May 2019 08:58 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/29422 (The current URI for this page, for reference purposes)
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