Jouyban, Abolghasem, Shokri, Javad, Barzegar-Jalali, Mohammad, Hassanzadeh, Davoud, Acree, William Eugene, Ghafourian, Taravat, Nokhodchi, Ali (2009) Solubility of chlordiazepoxide,diazepam,and lorazepam in ethanol+water mixtures at 303.2 K. Journal of Chemical and Engineering Data, 54 (7). pp. 2142-2145. ISSN 00219568 (ISSN). (doi:10.1021/je900200k) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:29422)
| The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. | |
| Official URL: http://dx.doi.org/10.1021/je900200k |
Abstract
Experimental solubilities of three benzodiazepines (chlordiazepoxide, diazepam,and lorazepam) in ethanol+water mixtures at 303.2 K are reported.The solubility of drugs was increased with the addition of ethanol and reached the maximum value of a volume fraction of 90 % of ethanol.The Jouyban-Acree model was used to fit the experimental data,and the solubilities were reproduced using previously trained version of the Jouyban-Acree model and the solubility data in monosolvents in which the overall mean relative deviations (OMRDs) of the models were 8.6 %,21.9 % and 19.3 %,respectively,for the fitted model,the trained version for ethanol+water mixtures and generally trained version for various organic solvents+water mixtures. © 2009 American Chemical Society.
| Item Type: | Article |
|---|---|
| DOI/Identification number: | 10.1021/je900200k |
| Additional information: | Unmapped bibliographic data: PY - 2009/// [EPrints field already has value set] AD - Faculty of Pharmacy and Drug Applied Research Center, Biotechnology Research Center, Research Center for Pharmaceutical Nanotechnology, Tabriz 51664, Iran [Field not mapped to EPrints] AD - Faculty of Pharmacy and Drug Applied Research Center, Tabriz University(Medical Sciences)., Denton,Texas 76203-5070 [Field not mapped to EPrints] AD - Biotechnology Research Center, Tabriz University (Medical Sciences), Research Center for Pharmaceutical Nanotechnology, Denton,Texas 76203-5070 [Field not mapped to EPrints] AD - Department of Chemistry, University of North Texas, Denton,Texas 76203-5070 [Field not mapped to EPrints] AD - Medway School of Pharmacy, Universities of Kent and Greenwich, Kent ME4 4TB, United Kingdom [Field not mapped to EPrints] JA - J Chem Eng Data [Field not mapped to EPrints] |
| Uncontrolled keywords: | Benzodiazepines, Experimental data, Jouyban-Acree model, Lorazepam, Maximum values, Relative deviations, Solubility data, Water mixture, Ethanol, Organic solvents, Ternary systems, Volume fraction, Solubility |
| Subjects: |
Q Science > QD Chemistry R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Divisions > Division of Natural Sciences > Medway School of Pharmacy |
| Depositing User: | Taravat Ghafourian |
| Date Deposited: | 29 Dec 2013 17:35 UTC |
| Last Modified: | 05 Nov 2024 10:10 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/29422 (The current URI for this page, for reference purposes) |
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