Diverse metabolic profiles of a Streptomyces strain isolated from a hyper-arid environment

Rateb, Mostafa E., Houssen, Wael E., Harrison, William T. A., Deng, Hai, Okoro, Chinyere K., Asenjo, Juan A., Andrews, Barbara A., Bull, Alan T., Goodfellow, Michael, Ebel, Rainer, and others. (2011) Diverse metabolic profiles of a Streptomyces strain isolated from a hyper-arid environment. Journal of Natural Products, 74 (9). pp. 1965-1971. ISSN 1520-6025. (doi:10.1021/np200470u) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:28337)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL: http://dx.doi.org/10.1021/np200470u

Abstract

The metabolic profile of Streptomyces sp. strain C34, isolated from the Chilean hyper-arid Atacama Desert soil, is dependent on the culture media used for its growth. The application of an OSMAC approach on this strain using a range of cultivation media resulted in the isolation and identification of three new compounds from the rare class of 22-membered macrolactone polyketides, named chaxalactins A-C (1-3). In addition, the known compounds deferroxamine E (4), hygromycin A (5), and 5?-dihydrohygromycin A (6) were detected. The isolated compounds were characterized by NMR spectroscopy and accurate mass spectrometric analysis. Compounds 1-3 displayed strong activity against Gram-positive but weak activity Gram-negative strains tested.

Item Type:	Article
DOI/Identification number:	10.1021/np200470u
Subjects:	Q Science
Divisions:	Divisions > Division of Natural Sciences > Biosciences
Depositing User:	Susan Davies
Date Deposited:	03 Nov 2011 11:44 UTC
Last Modified:	05 Nov 2024 10:09 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/28337 (The current URI for this page, for reference purposes)

University of Kent Author Information

Bull, Alan T..

Creator's ORCID:	https://orcid.org/0000-0001-6223-7722
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