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Dietary restriction delays aging, but not neuronal dysfunction, in Drosophila models of Alzheimer's disease.

Kerr, Fiona, Augustin, Hrvoje, Piper, Matthew D.W., Gandy, Carina, Allen, Marcus J., Lovestone, Simon, Partridge, Linda (2011) Dietary restriction delays aging, but not neuronal dysfunction, in Drosophila models of Alzheimer's disease. Neurobiology of Aging, 32 (11). pp. 1977-1989. ISSN 0197-4580. (doi:10.1016/j.neurobiolaging.2009.10.015) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:28321)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL:
http://dx.doi.org/10.1016/j.neurobiolaging.2009.10...

Abstract

Dietary restriction (DR) extends lifespan in diverse organisms and, in animal and cellular models, can delay a range of aging-related diseases including Alzheimer's disease (AD). A better understanding of the mechanisms mediating these interactions, however, may reveal novel pathways involved in AD pathogenesis, and potential targets for disease-modifying treatments and biomarkers for disease progression. Drosophila models of AD have recently been developed and, due to their short lifespan and susceptibility to genetic manipulation, we have used the fly to investigate the molecular connections among diet, aging and AD pathology. DR extended lifespan in both Arctic mutant A?42 and WT 4R tau over-expressing flies, but the underlying molecular pathology was not altered and neuronal dysfunction was not prevented by dietary manipulation. Our data suggest that DR may alter aging through generalised mechanisms independent of the specific pathways underlying AD pathogenesis in the fly, and hence that lifespan-extending manipulations may have varying effects on aging and functional declines in aging-related diseases. Alternatively, our analysis of the specific effects of DR on neuronal toxicity downstream of A? and tau pathologies with negative results may simply confirm that the neuro-protective effects of DR are upstream of the initiating events involved in the pathogenesis of AD.

Item Type: Article
DOI/Identification number: 10.1016/j.neurobiolaging.2009.10.015
Subjects: Q Science
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: Susan Davies
Date Deposited: 27 Oct 2011 09:50 UTC
Last Modified: 16 Nov 2021 10:06 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/28321 (The current URI for this page, for reference purposes)

University of Kent Author Information

Allen, Marcus J..

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