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The patterning and alignment of muscle cells using the selective adhesion of poly(oligoethylene glycol methyl ether methacrylate)-based ABA block copolymers

Popescu, Daniela C., Lems, R., Rossi, Nicholas A. A., Yeoh, Chert-Tsun, Loos, J., Holder, Simon J., Bouten, C.V.C., Sommerdijk, Najm (2005) The patterning and alignment of muscle cells using the selective adhesion of poly(oligoethylene glycol methyl ether methacrylate)-based ABA block copolymers. Advanced Materials, 17 (19). 2324-+. ISSN 0935-9648. (doi:10.1002/adma.200500039) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1002/adma.200500039

Abstract

The selective adhesion/delamination behavior of poly(oligoethylene glycol methyl ether methacrylate)-based ABA block copolymers is exploited to generate patterned substrates consisting of alternating lanes of glass and copolymer-coated gold. These patterns have been successfully used for the patterning and alignment of C2C12 muscle cells. The parallel-oriented myotubes (see Figure) contract upon electrical stimulation, forming a promising 2D in-vitro model for muscles.

Item Type: Article
DOI/Identification number: 10.1002/adma.200500039
Additional information: 42 WILEY-V C H VERLAG GMBH
Subjects: Q Science > QD Chemistry
Divisions: Faculties > Sciences > School of Physical Sciences > Functional Materials Group
Depositing User: Simon Holder
Date Deposited: 29 Aug 2008 15:01 UTC
Last Modified: 01 Aug 2019 10:29 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/2563 (The current URI for this page, for reference purposes)
Holder, Simon J.: https://orcid.org/0000-0001-8977-9257
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