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Fission yeast Myo51 is a meiotic spindle pole body component with discrete roles during cell fusion and spore formation.

Doyle, Alex, Martín-García, Rebeca, Coulton, Arthur T., Bagley, Steve, Mulvihill, Daniel P. (2009) Fission yeast Myo51 is a meiotic spindle pole body component with discrete roles during cell fusion and spore formation. Journal of Cell Science, 122 (24). pp. 4330-4340. ISSN 0021-9533. (doi:10.1242/jcs.055202) (KAR id:23286)

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Class V myosins are dimeric actin-associated motor proteins that deliver cellular cargoes to discrete cellular locations. Fission yeast possess two class V myosins, Myo51 and Myo52. Although Myo52 has been shown to have roles in vacuole distribution, cytokinesis and cell growth, Myo51 has no as yet discernible function in the vegetative life cycle. Here, we uncover distinct functions for this motor protein during mating and meiosis. Not only does Myo51 transiently localise to a foci at the site of cell fusion upon conjugation, but overexpression of the Myo51 globular tail also leads to disruption of cell fusion. Upon completion of meiotic prophase Myo51 localises to the outside of the spindle pole bodies (SPBs), where it remains until completion of meiosis II. Association of Myo51 with SPBs is not dependent upon actin or the septation initiation network (SIN); however, it is dependent on a stable microtubule cytoskeleton and the presence of the Cdc2-CyclinB complex. We observe a rapid and dynamic exchange of Myo51 at the SPB during meiosis I but not meiosis II. Finally, we show that Myo51 has an important role in regulating spore formation upon completion of meiosis.

Item Type: Article
DOI/Identification number: 10.1242/jcs.055202
Additional information: Research Article
Uncontrolled keywords: Schizosaccharomyces pombe, Myosin V, Meiosis, SPB, Spore formation, Fission yeast, Myo51
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QH Natural history > QH426 Genetics
Divisions: Divisions > Division of Natural Sciences > Biosciences
Funders: Biotechnology and Biological Sciences Research Council (
Cancer Research UK (
Depositing User: Daniel Mulvihill
Date Deposited: 10 Nov 2009 12:07 UTC
Last Modified: 12 Jul 2022 10:40 UTC
Resource URI: (The current URI for this page, for reference purposes)
Mulvihill, Daniel P.:
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