d'Antonio, Antonio, Losito, Simona, Pignata, Sandro, Grassi, Michele, Perrone, Francesco, de Luca, Antonella, Tambaro, Rosa, Bianco, Caterina, Gullick, William J., Johnson, Gibbes R., and others. (2002) Transforming growth factor alpha, amphiregulin and cripto- 1 are frequently expressed in advanced ovarian carcinomas. International Journal of Oncology, 21 (5). pp. 941-948. ISSN 1019-6439. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:22655)
| The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. |
Abstract
The expression of transforming growth factor alpha (TGFalpha), amphiregulin (AR) and cripto-1 (CR-1) was assessed by immunohistochemistry in 83 specimens (59 primary ovarian tumors and 24 extra-ovarian carcinomas) that were obtained from 68 ovarian carcinoma patients. Within the 59 primary tumors, 54 (92%) expressed immunoreactive TGFalpha, 45 (76%) expressed AR, and 28 (47%) expressed CR-1. The expression of AR and CR-1 mRNAs in the ovarian carcinomas was also demonstrated by RT-PCR analysis. Seventeen extra-ovarian specimens (71%) were found to express CR-1, whereas AR and TGFalpha were expressed respectively in 21 (87%) and 22 (92%) extra-ovarian tissues. In 15 cases for whom both ovarian and extra-ovarian tissues were available, a statistically significant higher expression of CR-1 was found in extra-ovarian specimens. A statistically significant correlation was found between AR expression in the ovarian carcinomas and both low grade and low proliferative activity. Finally, expression of TGFalpha was predictive of longer progression-free survival. These data strongly suggest that the EGF-related peptides might be involved in the pathogenesis and outcome of human ovarian cancer.
| Item Type: | Article |
|---|---|
| Uncontrolled keywords: | cripto-1; amphiregulin; TGF alpha; ovarian cancer; prognosis |
| Subjects: |
Q Science R Medicine > RC Internal medicine > RC254 Neoplasms. Tumors. Oncology |
| Divisions: | Divisions > Division of Natural Sciences > Biosciences |
| Depositing User: | William Gullick |
| Date Deposited: | 25 Sep 2009 13:18 UTC |
| Last Modified: | 05 Nov 2024 10:01 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/22655 (The current URI for this page, for reference purposes) |
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