Differencial Synthesis of Glyceraldehyde-3-Phosphate Dehydrogenase Polypeptide in Stressed Yeast-Cells

Boucherie, Helian, Bataille, Nelly, Fitch, Ian T., Perrot, Michel, Tuite, Mick F. (1995) Differencial Synthesis of Glyceraldehyde-3-Phosphate Dehydrogenase Polypeptide in Stressed Yeast-Cells. FEMS Microbiology Letters, 125 (2-3). pp. 127-133. ISSN 0378-1097. (doi:10.1016/0378-1097(94)00484-9) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:19713)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL: http://dx.doi.org/10.1016/0378-1097(94)00484-9

Abstract

Three unlinked genes, TDH1, TDH2 and TDH3, encode the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (triose-phosphate dehydrogenase; TDH) in the yeast Saccharomyces cervisiae. We demonstrate that the synthesis of the three encoded TDH polypeptides (TDHa, TDHb and TDHc, respectively) is not co-ordinately regulated and that TDHa is only synthesised as cells enter stationary phase, due to glucose starvation, or in heat-shocked cells. Furthermore, the synthesis of TDHb, but not TDHc, is strongly repressed by a heat shock. Hence, the TDHa enzyme may play a cellular role, distinct from glycolysis, that is required by stressed cells.

Item Type:	Article
DOI/Identification number:	10.1016/0378-1097(94)00484-9
Uncontrolled keywords:	SACCHAROMYCES CEREVISIAE; TRIOSE PHOSPHATE DEHYDROGENASE (GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE) STRESS RESPONSE; HEAT SHOCK
Subjects:	Q Science > QP Physiology (Living systems) > QP517 Biochemistry
Divisions:	Divisions > Division of Natural Sciences > Biosciences
Depositing User:	P. Ogbuji
Date Deposited:	08 Jun 2009 09:05 UTC
Last Modified:	05 Nov 2024 09:56 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/19713 (The current URI for this page, for reference purposes)

University of Kent Author Information

Tuite, Mick F..

Creator's ORCID:	https://orcid.org/0000-0002-5214-540X
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