Microcalorimetry in the Screening of Discovery Compounds and in the Investigation of Novel Drug-Delivery systems

Beezer, Anthony E., Mitchell, John C., Colegate, Rachel M., Scally, David J., Twyman, Lance J., Willson, Richard J. (1995) Microcalorimetry in the Screening of Discovery Compounds and in the Investigation of Novel Drug-Delivery systems. Thermochimica Acta, 250 (2). pp. 277-283. ISSN 0040-6031. (doi:10.1016/0040-6031(94)01966-K) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:19699)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL: http://dx.doi.org/10.1016/0040-6031(94)01966-K

Abstract

Calorimetry has for some time been proposed as a rapid method for determination of bioactivity. This paper describes the background to this application and describes how it has been extended to the study of bioassay techniques via microcalorimetry in the development of structure activity relationships (sARs). That sARs can be developed indicates that it is possible to guide drug synthetic strategy through the results of microcalorimetric investigations, and this approach is explored here. In an extension of this approach it is argued that microcalorimetry is well suited to the examination of novel drug delivery systems, allowing investigation of the capacity of drug delivery molecules to release the drug in the presence of a target organism.

Item Type:	Article
DOI/Identification number:	10.1016/0040-6031(94)01966-K
Uncontrolled keywords:	Bioassay, Dendrimer, Drug delivery, Microcalorimetry
Subjects:	Q Science > QD Chemistry
Divisions:	Divisions > Division of Computing, Engineering and Mathematical Sciences > School of Computing
Depositing User:	P. Ogbuji
Date Deposited:	08 Jun 2009 11:19 UTC
Last Modified:	05 Nov 2024 09:56 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/19699 (The current URI for this page, for reference purposes)

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