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Novel biotransformations to produce aromatic and heterocyclic aldehydes

Simmonds, J., Robinson, Gary K. (1997) Novel biotransformations to produce aromatic and heterocyclic aldehydes. Enzyme and Microbial Technology, 21 (5). pp. 367-374. ISSN 0141-0229. (doi:10.1016/S0141-0229(97)86532-5) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:17951)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL:
http://dx.doi.org/10.1016/S0141-0229(97)86532-5

Abstract

Aromatic aldehydes may be produced by Pseudomonas putida ATCC 12633 via biotransformation of benzoylformate and substrate analogues using the mandelic acid pathway. A reduction in pH to 5.4 causes the partial inactivation of the benzaldehyde dehydrogenase isoenzymes within this pathway, thereby allowing the accumulation of the aldehyde. The reduction in dehydrogenase activity with pH is a general phenomenon affecting all dehydrogenases within the cell and is not restricted to the benzaldehyde dehydrogenases of the mandelate pathway. Both benzaldehyde and thiophene-2-carboxaldehyde have been produced with yields of over 85%. (C) 1997 Elsevier Science Inc.

Item Type: Article
DOI/Identification number: 10.1016/S0141-0229(97)86532-5
Uncontrolled keywords: Pseudomonas putida ATCC 12633; benzaldehyde; aldehyde dehydrogenase; pH; mandelate pathway
Subjects: Q Science > QR Microbiology
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: T.J. Sango
Date Deposited: 13 May 2009 06:08 UTC
Last Modified: 16 Nov 2021 09:56 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/17951 (The current URI for this page, for reference purposes)

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