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Caboxamycin, a new antibiotic of the benzoxazole family produced by the deep-sea strain Streptomyces sp. NTK 937(*)

Hohmann, Claudia, Schneider, Kathrin, Bruntner, Christina, Irran, Elisabeth, Nicholson, Graeme, Bull, Alan T., Jones, Amanda L., Brown, Roselyn, Stach, James E.M., Goodfellow, Michael, and others. (2009) Caboxamycin, a new antibiotic of the benzoxazole family produced by the deep-sea strain Streptomyces sp. NTK 937(*). Journal Antibiot (Tokyo), 62 (2). pp. 99-104. ISSN 0021-8820. (doi:10.1038/ja.2008.24) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1038/ja.2008.24

Abstract

Caboxamycin, a new benzoxazole antibiotic, was detected by HPLC-diode array screening in extracts of the marine strain Streptomyces sp. NTK 937, which was isolated from deep-sea sediment collected in the Canary Basin. The structure of caboxamycin was determined by mass spectrometry, NMR experiments and X-ray analysis. It showed inhibitory activity against Gram-positive bacteria, selected human tumor cell lines and the enzyme phosphodiesterase.The Journal of Antibiotics (2009) 62, 99-104; doi:10.1038/ja.2008.24; published online 23 January 2009.

Item Type: Article
DOI/Identification number: 10.1038/ja.2008.24
Uncontrolled keywords: benzoxazole antibiotic, fermentation, isolation, marine Streptomyces, structural elucidation
Subjects: Q Science
R Medicine > RS Pharmacy and materia medica
Q Science > QR Microbiology
Divisions: Faculties > Sciences > School of Biosciences > Biomedical Research Group
Depositing User: Sue Davies
Date Deposited: 12 Aug 2009 09:17 UTC
Last Modified: 28 May 2019 13:56 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/17850 (The current URI for this page, for reference purposes)
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