Caboxamycin, a new antibiotic of the benzoxazole family produced by the deep-sea strain Streptomyces sp. NTK 937(*)

Hohmann, Claudia, Schneider, Kathrin, Bruntner, Christina, Irran, Elisabeth, Nicholson, Graeme, Bull, Alan T., Jones, Amanda L., Brown, Roselyn, Stach, James E.M., Goodfellow, Michael, and others. (2009) Caboxamycin, a new antibiotic of the benzoxazole family produced by the deep-sea strain Streptomyces sp. NTK 937(*). Journal Antibiot (Tokyo), 62 (2). pp. 99-104. ISSN 0021-8820. (doi:10.1038/ja.2008.24) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:17850)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL: http://dx.doi.org/10.1038/ja.2008.24
Additional URLs: http://hdl.handle.net/10145/69484 Organisation Publisher Organisation

Abstract

Caboxamycin, a new benzoxazole antibiotic, was detected by HPLC-diode array screening in extracts of the marine strain Streptomyces sp. NTK 937, which was isolated from deep-sea sediment collected in the Canary Basin. The structure of caboxamycin was determined by mass spectrometry, NMR experiments and X-ray analysis. It showed inhibitory activity against Gram-positive bacteria, selected human tumor cell lines and the enzyme phosphodiesterase.The Journal of Antibiotics (2009) 62, 99-104; doi:10.1038/ja.2008.24; published online 23 January 2009.

Item Type:	Article
DOI/Identification number:	10.1038/ja.2008.24
Uncontrolled keywords:	benzoxazole antibiotic, fermentation, isolation, marine Streptomyces, structural elucidation
Subjects:	Q Science R Medicine > RS Pharmacy and materia medica Q Science > QR Microbiology
Institutional Unit:	Schools > School of Natural Sciences > Biosciences
Former Institutional Unit:	Divisions > Division of Natural Sciences > Biosciences
Depositing User:	Susan Davies
Date Deposited:	12 Aug 2009 09:17 UTC
Last Modified:	20 May 2025 09:14 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/17850 (The current URI for this page, for reference purposes)

University of Kent Author Information

Bull, Alan T..

Creator's ORCID:	https://orcid.org/0000-0001-6223-7722
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