Bushell, M.E., Bull, Alan T. (1999) Sporulation at minimum specific growth rate in Aspergillus nidulans chemostat culture predicted using protein synthesis efficiency estimations. Journal of Basic Microbiology, 39 (5-6). pp. 293-298. ISSN 0233-111X. (doi:10.1002/(SICI)1521-4028(199912)39:5/6<293::AID-JOBM293>3.0.CO;2-C) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:17156)
The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. | |
Official URL: http://dx.doi.org/10.1002/(SICI)1521-4028(199912)3... |
Abstract
Ribosomal efficiency (RE) estimates provide a quantitative descriptor of intrinsic growth rate of cell populations using readily-obtainable experimental data. In Aspergillus nidulans chemostat cultures, RE increased linearly with growth rate over the range 25-60% of maximum growth rate (mu(max)) consistent with increasing ribosomal usage with increased growth rate. Above 60%, RE did not in crease significantly, suggesting that all ribosomes were functional at 60% of mu(max), further increases in growth rate, presumably resulting from increased polypeptide chain elongation rate. Extrapolating the linear part of the RE/growth rate curve predicted zero RE at a growth rate of 0.04 h(-1). Chemostat steady state cultures at 0.04 h(-1) contained spores (conidia), apparently undergoing a continuous sporulation/germination cycle. We propose that the RE estimates provide a means of predicting the value of minimum specific growth rate (mu(min)) below which net growth cannot take place.
Item Type: | Article |
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DOI/Identification number: | 10.1002/(SICI)1521-4028(199912)39:5/6<293::AID-JOBM293>3.0.CO;2-C |
Subjects: | Q Science |
Divisions: | Divisions > Division of Natural Sciences > Biosciences |
Depositing User: | M. Nasiriavanaki |
Date Deposited: | 03 Jul 2009 06:57 UTC |
Last Modified: | 05 Nov 2024 09:52 UTC |
Resource URI: | https://kar.kent.ac.uk/id/eprint/17156 (The current URI for this page, for reference purposes) |
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