An artificial immune system for evolving amino acid clusters tailored to protein function prediction

Secker, Andrew D. and Davies, Matthew N. and Freitas, Alex A. and Timmis, Jon and Clark, Edward and Flower, Darren R. (2008) An artificial immune system for evolving amino acid clusters tailored to protein function prediction. In: Bentley, Peter J. and Lee, Doheon and Jung, Sungwon, eds. Artificial Immune Systems. Lecture Notes in Computer Science / Lecture Notes in Artificial Intelligence . Springer, pp. 242-253. ISBN 978-3-540-85071-7. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:15659)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.

Abstract

This paper addresses the classification task of data mining (a form of supervised learning) in the context of an important bioinformatics problem, namely the prediction of protein functions. This problem is cast as a hierarchical classification problem, where the protein functions to be predicted correspond to classes that are arranged in a hierarchical structure, in the form of a class tree. The main contribution of this paper is to propose a new Artificial Immune System that creates a new representation for proteins, in order to maximize the predictive accuracy of a hierarchical classification algorithm applied to the corresponding protein function prediction problem.

Item Type:	Book section
Uncontrolled keywords:	artificial immune systems; data mining; bioinformatics; classification; clustering
Subjects:	Q Science > QA Mathematics (inc Computing science) > QA 75 Electronic computers. Computer science Q Science > Q Science (General) > Q335 Artificial intelligence
Divisions:	Divisions > Division of Computing, Engineering and Mathematical Sciences > School of Computing
Depositing User:	Maureen Cook
Date Deposited:	26 Mar 2009 09:43 UTC
Last Modified:	05 Nov 2024 09:50 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/15659 (The current URI for this page, for reference purposes)

University of Kent Author Information

Secker, Andrew D..

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Freitas, Alex A..

Creator's ORCID:	https://orcid.org/0000-0001-9825-4700
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Timmis, Jon.

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