Zhang, Fan, Skoda, M.W.A., Jacobs, R.M.J., Zorn, S., Martin, Richard A., Martin, C.M., Clark, G.F., Weggler, S., Hildebrandt, A., Kohlbacher, O., and others. (2008) Reentrant condensation of proteins in solution induced by multivalent counterions. Physical Review Letters: Moving Physics Forward, 101 (14). ISSN 0031-9007. (doi:10.1103/PhysRevLett.101.148101) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:15348)
| The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. | |
| Official URL: http://dx.doi.org/10.1103/PhysRevLett.101.148101 |
Abstract
Negatively charged globular proteins in solution undergo a condensation upon adding trivalent counterions between two critical concentrations C* and C**, C* < C**. This reentrant condensation behavior above C** is caused by short- ranged electrostatic interactions between multivalent cations and acidic residues, mechanistically different from the case of DNA. Small-angle x-ray scattering indicates a short- ranged attraction between counterion-bound proteins near C* and C**. Monte Carlo simulations (under these strong electrostatic coupling conditions) support an effective inversion of charge on surface side chains through binding of the multivalent counterions.
| Item Type: | Article |
|---|---|
| DOI/Identification number: | 10.1103/PhysRevLett.101.148101 |
| Additional information: | Article Number: 148101 |
| Subjects: | Q Science > QC Physics |
| Divisions: | Divisions > Division of Natural Sciences > Physics and Astronomy |
| Depositing User: | Louise Dorman |
| Date Deposited: | 27 Aug 2009 14:23 UTC |
| Last Modified: | 12 Jul 2022 10:39 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/15348 (The current URI for this page, for reference purposes) |
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