Reentrant condensation of proteins in solution induced by multivalent counterions

Zhang, Fan, Skoda, M.W.A., Jacobs, R.M.J., Zorn, S., Martin, Richard A., Martin, C.M., Clark, G.F., Weggler, S., Hildebrandt, A., Kohlbacher, O., and others. (2008) Reentrant condensation of proteins in solution induced by multivalent counterions. Physical Review Letters: Moving Physics Forward, 101 (14). ISSN 0031-9007. (doi:10.1103/PhysRevLett.101.148101) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:15348)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL: http://dx.doi.org/10.1103/PhysRevLett.101.148101

Abstract

Negatively charged globular proteins in solution undergo a condensation upon adding trivalent counterions between two critical concentrations C* and C**, C* < C**. This reentrant condensation behavior above C** is caused by short- ranged electrostatic interactions between multivalent cations and acidic residues, mechanistically different from the case of DNA. Small-angle x-ray scattering indicates a short- ranged attraction between counterion-bound proteins near C* and C**. Monte Carlo simulations (under these strong electrostatic coupling conditions) support an effective inversion of charge on surface side chains through binding of the multivalent counterions.

Item Type:	Article
DOI/Identification number:	10.1103/PhysRevLett.101.148101
Additional information:	Article Number: 148101
Subjects:	Q Science > QC Physics
Institutional Unit:	Schools > School of Engineering, Mathematics and Physics > Physics and Astronomy
Former Institutional Unit:	Divisions > Division of Natural Sciences > Physics and Astronomy
Depositing User:	Louise Dorman
Date Deposited:	27 Aug 2009 14:23 UTC
Last Modified:	20 May 2025 09:31 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/15348 (The current URI for this page, for reference purposes)

University of Kent Author Information

Martin, Richard A..

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