Schulze-Neick, Ingram, Hartenstein, Paulina, Li, Jia, Stiller, Brigitte, Nagdyman, Nicola, Hubler, Michael, Butrous, Ghazwan S., Petros, Andy, Lange, Peter, Redington, Andrew N. and others. (2003) Intravenous sildenafil is a potent pulmonary vasodilator in children with congenital heart disease. Circulation, 108 (10). pp. 167-173. ISSN 0009-7322. (doi:10.1161/01.cir.0000087384.76615.60) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:12271)
The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. | |
Official URL: https://doi.org/10.1161/01.cir.0000087384.76615.60 |
Abstract
Background-Increased pulmonary vascular resistance (PVR) because of congenital heart disease (CHD) may be caused by a dysfunction in endogenous pulmonary endothelial nitric oxide (NO) production. In other forms of pulmonary vascular disease with increased PVR, an elevated activity of a phosphodiesterase type 5 (PDE-5), responsible for the degradation of cyclic guanidine monophosphate (cGMP), the second messenger of endothelially produced NO, has been demonstrated. This study compares the effects of inhaled NO before and after the specific inhibition of the PDE-5 by intravenous sildenafil (Viagra T) in pre- and postoperative children with increased PVR because of CHD.
Item Type: | Article |
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DOI/Identification number: | 10.1161/01.cir.0000087384.76615.60 |
Additional information: | NOT IN FILE |
Subjects: | R Medicine > R Medicine (General) |
Divisions: | Divisions > Division for the Study of Law, Society and Social Justice > School of Social Policy, Sociology and Social Research |
Depositing User: | M.P. Stone |
Date Deposited: | 12 Sep 2008 11:24 UTC |
Last Modified: | 05 Nov 2024 09:45 UTC |
Resource URI: | https://kar.kent.ac.uk/id/eprint/12271 (The current URI for this page, for reference purposes) |
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