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A randomised cross-over study on the haemodynamic effects of oral dofetilide compared with oral sotalol in patients with ischaemic heart disease and sustained ventricular tachycardia

Boriani, Giuseppe, Biffi, Mauro, Bacchi, Letizia, Martignani, Cristian, Zannoli, Romano, Butrous, Ghazwan S., Branzi, Angelo (2002) A randomised cross-over study on the haemodynamic effects of oral dofetilide compared with oral sotalol in patients with ischaemic heart disease and sustained ventricular tachycardia. European Journal of Clinical Pharmacology, 58 (3). pp. 165-169. ISSN 0031-6970. (doi:10.1007/s00228-002-0464-3) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:12038)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL:
http://dx.doi.org/10.1007/s00228-002-0464-3

Abstract

Objective. To assess the haemodynamic effects of short-term treatment with dofetilide in comparison with sotalol in patients with ischaemic heart disease. Methods. Twelve patients with ischaemic heart disease and sustained ventricular tachycardia were treated with dofetilide [500 æg twice daily (b.i.d.)] or sotalol (160 mg b.i.d., randomised sequence separated by wash-out period) for 3-5 days. Right-heart catheterisation was performed at baseline and at the end of each short-term treatment phase. Results. The main findings were a significant reduction in heart rate, mean systemic pressure and cardiac index (-13%) during treatment with sotalol. Conversely, cardiac index increased significantly during dofetilide (mean percentage change 11%) with no effect on heart rate and systemic blood pressure. Conclusions. Oral dofetilide exerts favourable haemodynamic effects in comparison with D,L -sotalol following short-term oral treatment. In view of these observations, the use of dofetilide may be proposed also in patients with ventricular tachyarrhythmias associated with impaired left-ventricular function. Whether the haemodynamic differences between dofetilide and D,L -sotalol are the basis for differences in tolerability remains to be evaluated.

Item Type: Article
DOI/Identification number: 10.1007/s00228-002-0464-3
Subjects: R Medicine
Divisions: Divisions > Division for the Study of Law, Society and Social Justice > School of Social Policy, Sociology and Social Research
Depositing User: M.P. Stone
Date Deposited: 14 Sep 2008 15:43 UTC
Last Modified: 16 Nov 2021 09:50 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/12038 (The current URI for this page, for reference purposes)

University of Kent Author Information

Butrous, Ghazwan S..

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