The effects of bioisostere substitution on the antimicrobial and physicochemical properties of supramolecular self-associating amphiphiles

Naicker, Pinky, Yacoub, Mariam, White, Lisa J., Balderston, Dominick, Hailey, Perry A., Sutton, J. Mark, Hind, Charlotte, Hiscock, Jennifer R. (2026) The effects of bioisostere substitution on the antimicrobial and physicochemical properties of supramolecular self-associating amphiphiles. RSC Medicinal Chemistry, . ISSN 2632-8682. (doi:10.1039/D6MD00091F) (KAR id:113383)

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Official URL: https://doi.org/10.1039/D6MD00091F

Abstract

The rise of antimicrobial resistance (AMR) is one of the greatest health threats facing the world today. Supramolecular self-associating amphiphiles (SSAs) have shown potential for development as novel antimicrobial agents. We now move to explore the systematic use of nonclassical bioisosteres within these systems for the first time, reporting enhanced antimicrobial efficacy against a variety of clinically relevent bacteria as a result.

Item Type:	Article
DOI/Identification number:	10.1039/D6MD00091F
Subjects:	Q Science > QD Chemistry > QD431 Organic Chemistry- Biochemistry- Proteins, peptides, amino acids
Institutional Unit:	Schools > School of Natural Sciences Schools > School of Natural Sciences > Chemistry and Forensic Science
Former Institutional Unit:	There are no former institutional units.
Funders:	UK Research and Innovation (https://ror.org/001aqnf71)
Depositing User:	Jennifer Hiscock
Date Deposited:	11 Mar 2026 12:00 UTC
Last Modified:	25 Mar 2026 03:58 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/113383 (The current URI for this page, for reference purposes)

University of Kent Author Information

Yacoub, Mariam.

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Balderston, Dominick.

Creator's ORCID:
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Hailey, Perry A..

Creator's ORCID:	https://orcid.org/0000-0002-8121-9674
CReDIT Contributor Roles:

Hiscock, Jennifer R..

Creator's ORCID:	https://orcid.org/0000-0002-1406-8802
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