Propagating prions in fungi and mammals

Tuite, Mick F. and Koloteva-Levine, Nadejda (2004) Propagating prions in fungi and mammals. Molecular Cell, 14 (5). pp. 541-552. ISSN 1097-2765. (The full text of this publication is not available from this repository)

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Prions constitute a rare class of protein, which can switch to a robust amyloid form and then propagate that form in the absence of a nucleic acid determinant, thereby creating a unique, protein-only infectious agent. Details of the mechanism that drives conversion to the prion form and then subsequent propagation of that form are beginning to emerge using a range of in vivo and in vitro approaches. Recent studies on both mammalian and fungal prions are providing a greater understanding of the structural features that distinguish prions from non-transmissible amyloids.

Item Type: Article
Additional information: 1097-2765 (Print) Journal Article Research Support, Non-U.S. Gov't Review
Uncontrolled keywords: Amyloid/metabolism Animals Cell-Free System Fungal Proteins/*metabolism Humans Mammals/*metabolism Models, Biological Prion Diseases/*metabolism/transmission Prions/chemistry/*metabolism Protein Folding Protein Structure, Tertiary/physiology
Subjects: Q Science > QR Microbiology
Divisions: Faculties > Science Technology and Medical Studies > School of Biosciences > Protein Science Group
Depositing User: Mick Tuite
Date Deposited: 02 Oct 2008 16:37
Last Modified: 10 Jun 2014 11:14
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