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Propagating prions in fungi and mammals

Tuite, Mick F., Koloteva-Levine, Nadejda (2004) Propagating prions in fungi and mammals. Molecular Cell, 14 (5). pp. 541-552. ISSN 1097-2765. (doi:10.1016/j.molcel.2004.05.012) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:11315)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
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Abstract

Prions constitute a rare class of protein, which can switch to a robust amyloid form and then propagate that form in the absence of a nucleic acid determinant, thereby creating a unique, protein-only infectious agent. Details of the mechanism that drives conversion to the prion form and then subsequent propagation of that form are beginning to emerge using a range of in vivo and in vitro approaches. Recent studies on both mammalian and fungal prions are providing a greater understanding of the structural features that distinguish prions from non-transmissible amyloids.

Item Type: Article
DOI/Identification number: 10.1016/j.molcel.2004.05.012
Additional information: 1097-2765 (Print) Journal Article Research Support, Non-U.S. Gov't Review
Uncontrolled keywords: Amyloid/metabolism Animals Cell-Free System Fungal Proteins/*metabolism Humans Mammals/*metabolism Models, Biological Prion Diseases/*metabolism/transmission Prions/chemistry/*metabolism Protein Folding Protein Structure, Tertiary/physiology
Subjects: Q Science > QR Microbiology
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: Michael Tuite
Date Deposited: 02 Oct 2008 16:37 UTC
Last Modified: 09 Mar 2023 11:30 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/11315 (The current URI for this page, for reference purposes)

University of Kent Author Information

Tuite, Mick F..

Creator's ORCID: https://orcid.org/0000-0002-5214-540X
CReDIT Contributor Roles:

Koloteva-Levine, Nadejda.

Creator's ORCID:
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